p;55 (10.1 %)
20 (3.7 %)
0 (0%)
Common
Lymphopenia
21 (3.9%)
12 (2.2%)
1 (0.2%)
Endocrine disorders
Very common
Hypothyroidism
69 (12.7 %)
7 (1.3%)
0 (0%)
Metabolism and nutrition disorders
Very Common
Decreased appetite a
205 (37.7%)
9 (1.7%)
0 (0%)
Common
Dehydration
33 (6.1%)
7 (1.3%)
1 (0.2%)
Psychiatric disorders
Common
Insomnia
22 (4.0%)
0 (0%)
0 (0%)
Common
Depression
15 (2.8%)
1 (0.2%)
0 (0%)
Nervous system disorders
Very common
Taste disturbance b
251 (46.1%)
1 (0.2%)
0 (0%)
Very common
Headache
82 (15.1%)
3 (0.6%)
0 (0%)
Common
Dizziness
38 (7.0%)
2 (0.4%)
0 (0%)
Common
Neuropathy peripheral
35 (6.4%)
2 (0.4%)
0 (0%)
Common
Paraesthesia
35 (6.4%)
0 (0%)
0 (0%)
Common
Hypoaesthesia
20 (3.7%)
0 (0%)
0 (0%)
Common
Hyperaesthesia
18 (3.3 %)
0 (0%)
0 (0%)
Eye disorders
Common
Lacrimation increased
39 (7.2%)
0 (0%)
0 (0%)
Common
Eyelid oedema
12 (2.2%)
0 (0%)
0 (0%)
Vascular disorders
Very common
Hypertension
149 (27.4%)
56 (10.3%)
0 (0%)
Common
Flushing
17 (3.1%)
0 (0%)
0 (0%)
Common
Hot flush
12 (2.2%)
0 (0%)
0 (0%)
Respiratory, thoracic and mediastinal disorders
Very common
Epistaxis
87 (16.0%)
3 (0.6%)
0 (0%)
Common
Dyspnoea
45 (8.3%)
6 (1.1%)
0 (0%)
Common
Pharyngolaryngeal pain
26 (4.8%)
2 (0.4%)
0 (0%)
Common
Cough
23 (4.2%)
0 (0%)
0 (0%)
Common
Dysphonia
16 (2.9%)
0 (0%)
0 (0%)
Common
Nasal dryness
14 (2.6%)
0 (0%)
0 (0%)
Common
Pleural effusion
12 (2.2%)
3 (0.6%)
0 (0%)
Common
Dyspnoea exertional
11 (2.0%)
0 (0%)
0 (0%)
Common
Nasal congestion
12 (2.2%)
0 (0%)
0 (0%)
Gastrointestinal disorders
Very common
Diarrhoea
326 (59.9%)
39 (7.2%)
0 (0%)
Very common
Nausea
290 (53.3%)
19 (3.5%)
0 (0%)
Very common
Stomatitis/aphthous stomatitis
192 (35.5%)
14 (2.6%)
0 (0%)
Very common
Dyspepsia
189 (34.7%)
8 (1.5%)
0 (0%)
Very common
Vomiting
180 (33.1%)
17 (3.1%)
0 (0%)
Very common
Abdominal pain c / distension
99 (18.2%)
9 (1.7%)
0 (0%)
Very common
Constipation
83 (15.3%)
1 (0.2%)
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