on
Dizziness
18 (4.1%)
1 (0.2%)
0 (0.0%)
Common
Neuropathy peripheral
11 (2.5%)
0 (0.0%)
0 (0.0%)
Common
Hypoaesthesia
10 (2.3%)
0 (0.0%)
0 (0.0%)
Vascular disorders
Very common
Hypertension
101 (23.0%)
43 (9.8%)
0 (0.0%)
Respiratory, thoracic and mediastinal disorders
Common
Epistaxis
28 (6.4%)
1 (0.2%)
0 (0.0%)
Common
Dyspnoea
16 (3.6%)
2 (0.5%)
0 (0.0%)
Renal and urinary disorders
Common
Chromaturia
18 (4.1%)
0 (0.0%)
0 (0.0%)
Gastrointestinal disorders
Very common
Diarrhoea
187 (42.5%)
24 (5.5%)
0 (0.0%)
Very common
Nausea
161 (36.6%)
15 (3.4%)
0 (0.0%)
Very common
Vomiting
98 (22.2%)
7 (1.6%)
0 (0.0%)
Very common
Stomatitis
90 (20.5%)
7 (1.6%)
0 (0.0%)
Very common
Dyspepsia
80 (18.2%)
4 (0.9%)
0 (0.0%)
Very common
Abdominal pain C / distension
77 (17.5%)
15 (3.4%)
2 (0.5%)
Very common
Flatulence
46 (10.5%)
0 (0.0%)
0 (0.0%)
Very common
Oral pain
44 (10.0%)
2 (0.5%)
0 (0.0%)
Common
Constipation
37 (8.4%)
2 (0.5%)
0 (0.0%)
Common
Glossodynia
37 (8.4%)
0 (0.0%)
0 (0.0%)
Common
Dry mouth
31 (7.0%)
0 (0.0%)
0 (0.0%)
Common
Gastro-oesophageal reflux disease
12 (2.7%)
1 (0.2%)
0 (0.0%)
Common
Mouth ulceration
11 (2.5%)
0 (0.0%)
0 (0.0%)
Common
Oral discomfort
11 (2.5%)
0 (0.0%)
0 (0.0%)
Skin and subcutaneous tissue disorders
Very common
Yellow skin/Skin discolouration
146 (33.2%)
0 (0.0%)
0 (0.0%)
Very common
Palmar-plantar erythrodysaesthesia syndrome
106 (24.1%)
27 (6.1%)
0 (0.0%)
Very common
Hair colour changes
67 (15.2%)
0 (0.0%)
0 (0.0%)
Very common
Rash
64 (14.5%)
3 (0.7%)
0 (0.0%)
Common
Dry skin
41 (9.3%)
0 (0.0%)
0 (0.0%)
Common
Alopecia
33 (7.5%)
0 (0.0%)
0 (0.0%)
Common
Dermatitis
29 (6.6%)
1 (0.2%)
0 (0.0%)
Common
Periorbital oedema
20 (4.5%)
0 (0.0%)
0 (0.0%)
Common
Skin Reaction
20 (4.5%)
3 (0.7%)
0 (0.0%)
Common
Erythema
18 (4.1%)
0 (0.0%)
0 (0.0%)
Common
Eczema
16 (3.6%)
1 (0.2%)
0 (0.0%)
Common
Pruritus
16 (3.6%)
0 (0.0%)
0 (0.0%)
Common
Skin hyperpigmentation
15 (3.4%)
0 (0.0%)
0 (0.0%)
Common
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