Febrile neutropenia
     Anemia
     Neutropenia
     Thrombocytopenia
     Leukopenia
     
    
25
18
16
11
9
     
23
13
15
8
8
 
Gastrointestinal disorders

     Nausea
     Constipation
     Diarrhea†
     Abdominal pain
     Vomiting
    
     
25
20
20
15
13
    
0
< 1
1
2
0
 
General disorders and administration site conditions

     Pyrexia
     Peripheral edema
     Fatigue
     Chills
     Chest pain
     
     
62
25
17
15
11
    
7
< 1
1
0
1
 
Immune system disorders

     Cytokine release syndrome
    
     
11
    
1
 
Infections and infestations

     Other pathogen infections
     Bacterial infections
     Fungal infections
     Viral infections
     Pneumonia
     Sepsis
    
44
19
15
13
9
7
    
25
12
7
4
8
6
 
Investigations
     Increased alanine aminotransferase
     Increased aspartate aminotransferase
     Increased weight
    

12
11
11
    

6
4
0
 
Metabolism and nutrition disorders

     Hypokalemia
     Hypomagnesemia
     Hyperglycemia
     Decreased appetite
     Hypophosphatemia
    
    
 
23
12
11
10
6
    
  
6
0
7
3
5
 
Musculoskeletal and connective tissue disorders

     Back pain
     Pain in extremity
     Bone pain
     Arthralgia
     
    
14
12
11
10
    
2
1
3
2
 
Nervous system disorders

     Headache
     Tremor‡
     Dizziness
    
    
36
20
14
   
3
1