have liver problems

are pregnant, think you may be pregnant, or are planning to become pregnant.

are breastfeeding or planning to breastfeed. Talk with your doctor about the best way to feed your baby if you take NEXIUM.

Tell your doctor about all of the medicines you take including prescription and non-prescription drugs, vitamins and herbal supplements. NEXIUM may affect how other medicines work, and other medicines may affect how NEXIUM works. Especially tell your doctor if you take:

warfarin (COUMADIN)

ketoconazole (NIZORAL)

voriconazole (VFEND)

atazanavir (REYATAZ)

nelfinavir (VIRACEPT)

saquinavir (FORTOVASE)

products that contain iron

digoxin (LANOXIN, LANOXICAPS)

St.John’s Wort (Hypericum perforatum)

Rifampin

HOW SHOULD I TAKE NEXIUM?

Take NEXIUM exactly as prescribed by your doctor.

Do not change your dose or stop NEXIUM without talking to your doctor.

Take NEXIUM at least 1 hour before a meal.

Swallow NEXIUM capsules whole. Never chew or crush NEXIUM.

If you have difficulty swallowing NEXIUM capsules, you may open the capsule and empty the contents into a tablespoon of applesauce. Be sure to swallow the applesauce right away. Do not store it for later use.

If you forget to take a dose of NEXIUM, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take a double dose to make up for a missed dose.

If you take too much NEXIUM, tell your doctor right away.

See the “Patient Instructions for Use” at the end of this leaflet for instructions how to take NEXIUM Delayed-Release Oral Suspension, and how to mix and give NEXIUM Delayed-Release Capsules and NEXIUM For Delayed-Release Oral Suspension, through a nasogastric tube or gastric tube.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF NEXIUM?

Serious allergic reactions. Tell your doctor if you get any of the following symptoms with NEXIUM.

rash

face swelling

throat tightness

difficulty breathing

Your doctor may stop NEXIUM if these symptoms happen.

Low magnesium levels in your body. This problem can be serious. Low magnesium can happen in some people who take a proton pump inhibitor medicine for at least 3 months. If low magnesium levels happen, it is usually after a year of treatment. You may or may not have symptoms of low magnesium.

Tell your doctor right away if you have any of these symptoms:

seizures

dizziness

abnormal or fast heart beat

jitteriness

jerking movements or shaking (tremors)

muscle weakness

spasms of the hands and feet

cramps or muscle aches

spasm of the voice box

Your doctor may check the level of magnesium in your body before you start taking NEXIUM or during treatment if you will be taking NEXIUM for a long period of time.

The most common side effects with NEXIUM may include:

Headache

Diarrhea

Nausea

Gas

Abdominal pain

Constipation

Dry mouth

Drowsiness

People who are taking multiple daily doses of proton pump inhibitor medicines for a long period of time may have an increased risk of fractures of the hip, wrist or spine.

Tell your doctor about any side effects that bother you or that do not go away. These are not all the possible side effects with NEXIUM. Talk with your doctor or pharmacist if you have any questions about side effects.

HOW