In these same studies of patients with erosive esophagitis, sustained heartburn resolution and time to sustained heartburn resolution were eva luated and are shown in the table below:

Table 11

Sustained Resolution* of Heartburn (Erosive Esophagitis Patients) *
Defined as 7 consecutive days with no heartburn reported in daily patient diary.
†
Defined as the cumulative proportion of patients who have reached the start of sustained resolution
‡
log-rank test vs omeprazole 20 mg
§
N.S. = not significant (p > 0.05)
   Cumulative Percent† with Sustained Resolution
 
Study
 No. of Patients
 Treatment Groups
 Day 14
 Day 28
 Significance Level ‡
 
1
 573
 NEXIUM 20 mg
 64.3%
 72.7%
 N.S.§
 
 555
 Omeprazole 20 mg
 64.1%
 70.9%
 
2
 621
 NEXIUM 40 mg
 64.8%
 74.2%
 p <0.001
 
 620
 NEXIUM 20 mg
 62.9%
 70.1%
 N.S.§
 
 626
 Omeprazole 20 mg
 56.5%
 66.6%
 
3
 568
 NEXIUM 40 mg
 65.4%
 73.9%
 N.S.§
 
 551
 Omeprazole 20 mg
 65.5%
 73.1%
 
4
 1187
 NEXIUM 40 mg
 67.6%
 75.1%
 p <0.001
 
 1188
 Omeprazole 20 mg
 62.5%
 70.8%
Defined as 7 consecutive days with no heartburn reported in daily patient diary.
†
D