ith Zollinger-Ellison syndrome the dose should be individually adjusted and treatment continued as long as clinically indicated. The recommended initial dose is Ulcid 60 mg daily. All patients with severe disease and inadequate response to other therapies have been effectively controlled and more than 90% of the patients maintained on doses of Ulcid 20-120mg daily. When dose exceed Ulcid 80 mg daily, the dose should be divided and given twice daily.
Posology in children
Children over 1 year of age and 10kg
Treatment of reflux esophagitis
Symptomatic treatment of heartburn and acid regurgitation in gastro-esophageal reflux disease
The posology recommendations are as follows:
Age
Weight
Posology
1 year of age
10-20 kg
10 mg once daily. The dose can be increased to 20 mg once daily if needed
2 years of age
> 20 kg
20mg once daily. The dose can be increased to 40 mg once daily if needed
Reflux esophagitis: The treatment time is 4–8 weeks.
Symptomatic treatment of heartburn and acid regurgitation in gastro-esophageal reflux disease: The treatment time is 2–4 weeks. If symptom control has not been achieved after 2–4 weeks the patient should be investigated further.
Children and adolescents over 4 years of age
Treatment of duodenal ulcer caused by H. pylori
When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents.
The treatment should be supervised by a specialist.
The posology recommendations are as follows:
Weight
Posology
15-30 kg
Combination with two antibiotics: omeprazole 10 mg, amoxicillin 25 mg/kg body weight and clarithromycin 7.5 mg/kg body weight are all administrated together two times daily for one week
31-40 kg
Combination with two antibiotics: Ulcid 20 mg, amoxicillin 750 mg and clarithromycin 7.5 mg/kg body weight are all administrated two times daily for one week
> 40 kg
Combination with two antibiotics: Ulcid 20 mg, amoxicillin 1 g and clarithromycin 500 mg are all administrated two times daily for one week.
Special populations
Impaired renal function
Dose adjustment is not needed in patients with impaired renal function (see section 5.2).
Impaired hepatic function
In patients with impaired hepatic function, a daily dose of 10-20 mg may be sufficient (see section 5.2).
Elderly (> 65 years old)
Dose adjustment is not needed in the elderly (see section 5.2)
Method of administration:
It is recommended to take Ulcid capsules in the morning, swallowed whole with half a glass of water. The capsules must not be chewed or crushed.
For patients with swallowing difficulties and for children who can drink or swallow semi-solid food
Patients can open the capsule and swallow the contents with half a glass of water or after mixing the contents in a slightly acidic fluid e.g., fruit juice or apple sauce or in non-carbonated water. Patients should be advised that the dispersion should be taken immediately (or within 30 minutes) and always be stirred just before drinking and rinsed down with half a glass of water. Alternati
