sophageal reflux disease
Adult: For patients without erosive oesophagitis: 20 mg once daily for 4 wk. Additional 4 wk may be considered in patients whose symptoms have not fully resolved after the 1st course.
Child: 10 mg once daily for up to 8 wk.
Hepatic impairment: Severe impairment (Child-Pugh class C): Not more than 20 mg daily.
Intravenous
Gastro-oesophageal reflux disease
Adult: For short term treatment only. 20 or 40 mg once daily for ≤10 days. Convert to oral therapy as soon as possible. May be administered by inj over at least 3 minutes, intermittent infusion (10-30 minutes) or continuous infusion (over up to 72 hr).
Hepatic impairment: Severe impairment (Child-Pugh class C): Not more than 20 mg daily.
Reconstitution
Each single-use vial contains 20 or 40 mg of esomeprazole. For IV inj: Reconstitute each vial with 5 ml of normal saline. For IV infusion: Reconstitute each vial with 5 ml of normal saline, lactated Ringer's inj or dextrose 5% inj, then further dilute the resultant solution to a final volume of 50 ml.
Food(before/after)
Delayed-release cap: Should be taken on an empty stomach. (Take on an empty stomach 1 hr before meals.)
Tab: May be taken with or without food.
List of Contraindications
Esomeprazole and Pregnancy
Caution when used during pregnancy.
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Esomeprazole and Lactation
Caution when used during lactation
Esomeprazole and Children
Information Not Available
Esomeprazole and Geriatic
Information Not Available
Esomeprazole and Other Contraindications
Hypersensitivity
Storage
Intravenous
Pwd for inj:
Store at 25°C (77°F). Protect from light. Reconstituted solution for inj should be stored at room temperature up to 30°C and administered within 12 hr after preparation. Reconstituted solution for infusion should be stored at room temperature up to 30°C and administered within 12 hr (if normal saline or lactated Ringer's inj is used as the diluent) or 6 hr (if dextrose 5% inj is used as the diluent).
Oral
Store at 25°C.
Lab interference
Increased creatinine, uric acid, bilirubin, alkaline phosphatase, ALT, AST. Altered thyroid function tests.
