Before you receive FOLOTYN, tell your doctor if you:

have liver problems.
have kidney problems.
have any other medical conditions.
are pregnant or plan to become pregnant. FOLOTYN can harm your unborn baby. Talk to your doctor about the best way to prevent pregnancy while taking FOLOTYN. Tell your doctor right away if you become pregnant while taking FOLOTYN.
are breast-feeding or plan to breast-feed. It is not known if FOLOTYN passes into breast milk. You and your doctor should decide if you will take FOLOTYN or breast-feed. You should not do both. Talk to your doctor about the best way to feed your baby while you are being treated with FOLOTYN.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how FOLOTYN works, and FOLOTYN may affect how other medicines works. Especially tell your doctor if you take:

sulfamethoxazole trimethoprim (Bactrim®, Septra®, Septra DS, Sulfatrim Pediatric, Sulfamethoprim, Sulfamethoprim-DS)
non-steroidal anti-inflammatory drugs (NSAIDs)
probenecid (Probalan, Col-Probenecid)
Ask your doctor or pharmacist if you are not sure if your medicine is listed above.

Know the medicines you take. Keep a list of them and show it to your doctor or pharmacist each time you start a new medicine.

How will I receive FOLOTYN?

FOLOTYN will be given to you as directed by your doctor, as an intravenous (IV) injection into your vein over 3 to 5 minutes.
FOLOTYN is usually given in cycles, one time each week for 6 weeks, with no treatment on the 7th week. Treatment with FOLOTYN may be continued as long as it is helpful to you.
To lower your chances of harmful side effects, it is important that you take folic acid and vitamin B12 during your treatment with FOLOTYN. Your doctor will give you specific instructions for vitamin supplementation.

You will take folic acid by mouth for 10 days before your first dose of FOLOTYN. Do not take more or less folic acid than your doctor tells you to take. Continue taking folic acid every day until your doctor tells you to stop.
Your doctor will give you a vitamin B12 injection into your muscle (intramuscular) before your first dose of FOLOTYN and about every 8 to 10weeks during treatment with FOLOTYN.
You should have regular blood tests before and during your treatment with FOLOTYN. Your doctor may change your dose of FOLOTYN or delay treatment based on the results of your blood tests and on your general condition.

What are the possible side effects of FOLOTYN?

FOLOTYN may cause serious side effects, including:

Low Blood Cell Counts: FOLOTYN can affect your bone marrow and cause you to have low blood cell counts. Your doctor will do blood tests as needed to check your blood cell counts.
Low Platelet Count (thrombocytopenia): Tell your doctor right away if you have any unusual bleeding, such as nosebleeds, or bruising under your skin.
Low White Blood Cell Count (neutropenia): A low white blood cell count can cause you to get infections, which may be serious. Serious illness or death can happen if an infection is not treated right away when white blood cell counts are very low. Tell your doctor right away if you have any of the following signs or symptoms of an infection:fever
chills
cough
 shortness of breath
pain or burning on urination
 

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