dose at the regular time.
•Do not take more than 1 dose of Zykadia™ at one time. Call your health care provider right away if you take too much.
•You should not drink grapefruit juice or eat grapefruit during your treatment with Zykadia™. It may make the amount of Zykadia™ in your blood increase to a harmful level.
•The amount of Zykadia™ that you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition being treated.
Side effects:
Important things to remember about the side effects of Zykadia™:
•Most people do not experience all of the side effects listed.
•Side effects are often predictable in terms of their onset and duration.
•Side effects are almost always reversible and will go away after treatment is complete.
•There are many options to help minimize or prevent side effects.
•There is no relationship between the presence or severity of side effects and the effectiveness of the medication.
The following side effects are common (occurring in greater than 30%) for patients taking Zykadia™:
•Diarrhea
•Hemoglobin decreased
•Increase in liver enzymes
•Nausea
•Vomiting
•Increase in creatinine
•Abdominal pain
•Fatigue
•Glucose increased
•Decrease in phosphate
•Decreased appetite
These side effects are less common side effects (occurring in about 10-29%) of patients receiving Zykadia™:
•Constipation
•Lipase increased
•Esophageal disorder (Heart burn, dyspepsia, dysphagia)
•Rash
•Bilirubin (total) increased
A serious, but very uncommon side effect of Zykadia™ is pneumonitis (swelling of the lungs). When this side effect occurred, it was often accompanied by breathing difficulty with cough or a low-grade fever requiring hospitalization. Symptoms may be similar to those symptoms from lung cancer. Contact your health care provider right away if you have any new or worsening symptoms.
Another serious but very uncommon side effect of Zykadia™ is EKG changes.
Not all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms.
When to contact your doctor or health care provider:
Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:
•Fever of 100.4° F (38° or higher, chills)
•Sudden onset of shortness of breath, chest pain, accompanied by cough (with or without mucus)
The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:
•Diarrhea (4-6 episodes in a 24-hour period)
•Nausea (interferes with ability to eat and unrelieved with prescribed medication).
•Vomiting (vomiting more than 4-5 times in a 24 hour period)
•Unable to eat or drink for 24 hours or have signs of dehydration: tiredness, thirst, dry mouth, dark and decrease amount of urine, or dizziness
•Skin or the whites of your eyes turn yellow
•Itchy skin
•Urine turns dark or brown (tea color)
•Decreased appetite
•Pain on the right side of your stomac |
