Do not take JANUMET if:

you are allergic to any of the ingredients in JANUMET. See the end of this Medication Guide for a complete list of ingredients in JANUMET.

Symptoms of a serious allergic reaction to JANUMET may include:
rash
raised red patches on your skin (hives)
swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing
you have kidneys which are not working properly.
you are going to get an injection of dye or contrast agents for an x-ray procedure, JANUMET will need to be stopped for a short time. Talk to your doctor about when you should stop JANUMET and when you should start JANUMET again. See “What is the most important information I should know about JANUMET?”.
What should I tell my doctor before taking JANUMET?

Before you take JANUMET, tell your doctor if you:

have or have had inflammation of your pancreas (pancreatitis).
have kidney problems.
have liver problems.
have heart problems, including congestive heart failure.
are older than 80 years. If you are over 80 years old you should not take JANUMET unless your kidneys have been checked and they are normal.
drink alcohol very often, or drink a lot of alcohol in short-term “binge” drinking.
have any other medical conditions.
are pregnant or plan to become pregnant. It is not known if JANUMET will harm your unborn baby. If you are pregnant, talk with your doctor about the best way to control your blood sugar while you are pregnant.
Pregnancy Registry: If you take JANUMET at any time during your pregnancy, talk with your doctor about how you can join the JANUMET pregnancy registry. The purpose of this registry is to collect information about the health of you and your baby. You can enroll in this registry by calling 1-800-986-8999.
are breast-feeding or plan to breast-feed. It is not known if JANUMET will pass into your breast milk. Talk with your doctor about the best way to feed your baby if you are taking JANUMET.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. JANUMET may affect how well other drugs work and some drugs can affect how well JANUMET works.

Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.

How should I take JANUMET?

Take JANUMET exactly as your doctor tells you.
Your doctor may change your dose of JANUMET if needed.
Your doctor may tell you to take JANUMET along with certain other diabetes medicines. Low blood sugar can happen more often when JANUMET is taken with certain other diabetes medicines. See "What are the possible side effects of JANUMET?".
Take JANUMET with meals to lower your chance of having an upset stomach.
Continue to take JANUMET as long as your doctor tells you.
If you take too much JANUMET, call your doctor or local Poison Control Center right away.
If you miss a dose, take it with food as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not take two doses of JANUMET at the same time.
You may need to stop taking JANUMET for