h and itch.
Disturbances in the normal levels of blood cells in the blood.
Yellowing of the skin and eyes (jaundice).
Disturbance in liver function.
Inflammation of the liver (hepatitis).
The side effects listed above may not include all of the sideeffects reported by the drug'smanufacturer.For moreinformation about any other possible risks associated with this medicine,please read the information provided with the medicine or consult your doctoror pharmacist.
How can this medicine affect other medicines?
Many medicines can affect blood sugar levels. It is important totell your doctor or pharmacist what medicines you are already taking, includingthose bought without a prescription and herbal medicines, before you starttreatment with this medicine. Similarly, check with your doctor or pharmacistbefore taking any new medicines while taking this one, to ensure that thecombination is safe.
The following medicines may enhance the blood sugar loweringeffect of this medicine and therefore increase the chance of low blood sugar(hypoglycaemia). If you start treatment with any of these your dose of thismedicine may therefore need decreasing:
anticoagulants, eg warfarin (anticoagulant effect may also be altered - if you are taking an anticoagulant with this medicine your doctor may want to perform extra monitoring of your blood clotting time or blood sugar)
ACE inhibitors, eg captopril, enalapril (these can cause unpredictable drops in blood sugar)
cimetidine
disopyramide
fibrates, eg clofibrate
fluconazole
insulin
MAOI antidepressants, eg phenelzine
miconazole (should not be taken with gliclazide)
other antidiabetic tablets
phenylbutazone
large doses of salicylates, eg aspirin (small pain relieving doses do not normally have this effect)
sulphonamide antibiotics, eg sulfamethoxazole, co-trimoxazole.
Beta-blockers, eg propranolol (including eye drops containingbeta-blockers) can mask some of the signs of low blood sugar, such as increasedheart rate and tremor. They also prolong episodes of low blood sugar and impairrecovery back to normal glucose levels.
The following medicines may increase blood glucose levels. Ifyou start treatment with any of these your dose of this medicine may thereforeneed increasing:
some antipsychotic medicines, eg chlorpromazine, olanzapine
corticosteroids, eg hydrocortisone, prednisolone
danazol
diuretics, especially thiazide diuretics, eg bendroflumethiazide
oestrogens and progesterones, such as those contained in oral contraceptives.
Other medicines containing the same active ingredient
Diamicron MR Vivazide
Gliclazide tablets are also available without a brand name, ieas thegeneric medicine.
