They are supplied as follows:

Package Strength NDC Code
Bottles of 10 500 mg 54868-0830-0
Bottles of 30 500 mg 54868-0830-1

Storage

Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F); see[USP Controlled Room Temperature]

Rx Only
Depomed, Inc.
Menlo Park, CA
(866) 458-6389
©2008 Depomed, Inc.
www.GlumetzaXR.com

Revised December 2008
GLU-001-C.1

Relabeling and Repackaging by:
Physicians Total Care, Inc.
Tulsa, OK 74146
PATIENT INFORMATION
Rx Only
GLUMETZA (Gloo-met-za) (metformin hydrochloride extended-release tablets)

Read this information carefully before you start taking this medicine and each time you refill your prescription. There may be new information. This information does not take the place of your doctor's advice. Ask your doctor or pharmacist if you do not understand some of this information or if you want to know more about this medicine.

What is the most important information I should know about GLUMETZA?

Warning: GLUMETZA can cause a rare, but serious condition called lactic acidosis (a buildup of an acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in the hospital. Stop taking GLUMETZA and call your doctor right away if you get the following symptoms of lactic acidosis.

You feel very weak or tired.
You have unusual (not normal) muscle pain.
You have trouble breathing.
You have stomach pain with nausea and vomiting, and diarrhea.
You feel cold, especially in your arms and legs.
You feel dizzy or lightheaded.
You have a slow or irregular heartbeat.
Your medical condition suddenly changes.
You have a higher chance for getting lactic acidosis with GLUMETZA if you:

have kidney or liver problems.
have congestive heart failure that requires treatments with medicines.
drink a lot of alcohol (very often or short-term "binge" drinking).
get dehydrated (lose a large amount of body fluids). This can happen if you are sick with a fever, vomiting, or diarrhea. Dehydration can also happen when you sweat a lot with activity or exercise and don't drink enough fluids.
have certain x-ray test with injectable dye used.
have surgery.
have a heart attack, severe infection, or a stroke.
are 80years of age or older and have not had your kidney function tested.

What is GLUMETZA?

GLUMETZA is used along with diet and exercise to improve blood sugar control in adults with type2 diabetes. GLUMETZA may also be used with another anti-diabetes medicine called a sulfonylurea or with insulin to improve blood sugar levels in adults. GLUMETZA helps control your blood sugar in a number of ways. These include helping your body respond better to the insulin it makes naturally, decreasing the amount of sugar your liver makes, and decreasing the amount of sugar your intestines absorb. GLUMETZA has not been studied in children under 18years of age.

Who should not take GLUMETZA?

Do not take GLUMETZA if you:

have kidney problems.
have heart failure that is treated with medicines.
have a condition called metabolic acidosis, including diabetic ketoacidosis. Diabetic ketoacidosis should be treated with insulin.
are allergic to GLUMETZA or to any of its ingredients. See the end of this leaflet for a list of ingredients in GLUMETZA.

What should I tell my do