ems, including liver failure, which can be severe and may lead to death. Your healthcare provider will do blood tests during your treatment with Iclusig to check for liver problems. Get medical help right away if you get any of these symptoms of liver problems during treatment:
•yellowing of your skin or the white part of your eyes (jaundice)
•nausea or vomiting
•dark "tea-colored" urine
•sleepiness
What is Iclusig?
Iclusig is a prescription medicine used to treat adults who have chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) or Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who are no longer benefiting from previous treatment, or who did not tolerate other treatment.
It is not known if Iclusig is safe and effective in children less than 18 years of age.
What should I tell my healthcare provider before taking Iclusig?
Before you take Iclusig, tell your healthcare provider if you:
•have a history of blood clots in your blood vessels (arteries or veins)
•have liver problems
•have heart problems, including heart failure, irregular heartbeats, and QT prolongation
•have had inflammation of your pancreas (pancreatitis)
•have high blood pressure
•have bleeding problems
•plan to have any surgical procedures
•are lactose (milk sugar) intolerant. Iclusig tablets contain lactose.
•drink grapefruit juice
•have any other medical conditions
•are pregnant or plan to become pregnant. Iclusig can harm your unborn baby. You should not become pregnant while taking Iclusig. Tell your healthcare provider right away if you become pregnant or plan to become pregnant.
•are breastfeeding or plan to breastfeed. It is not known if Iclusig passes into your breast milk. You and your healthcare provider should decide if you will take Iclusig or breastfeed. You should not do both.
Tell your healthcare provider about all the medicines you take, including prescription medicines and over-the-counter medicines, vitamins, and herbal supplements. Iclusig and other medicines may affect each other causing side effects.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take Iclusig?
•Take Iclusig exactly as your healthcare provider tells you.
•Your healthcare provider may change your dose of Iclusig or tell you to stop taking Iclusig.
•Do not change your dose or stop taking Iclusig without talking to your healthcare provider.
•Swallow Iclusig tablets whole. Do not crush or dissolve Iclusig tablets.
•If you miss a dose of Iclusig, take your next dose at your regular time. Do not take 2 doses at the same time to make up for a missed dose.
•If you take too much Iclusig, call your healthcare provider or go to the nearest hospital emergency room right away.
What are the possible side effects of Iclusig?
Iclusig may cause serious side effects, including:
•See "What is the most important information I should know about Iclusig?"
•High blood pressure. Your blood pressure should be checked regularly and any high blood pressure should be treated while you are taking Iclusig. Tell your healthcare provider if you get headaches, dizziness, chest pain or shortness of breath.
•Heart problems.
