Thrombocytopenia

(4.3%) (G3/4: 0.7%)
   Disseminated intravascular coagulationb
 
Metabolism and nutrition disorders
 Decreased appetite

(21.9%) (G3/4: 0.7%)
 Hypokalaemia (6.1%) (G3/4: 1.7%)

Hypomagnesaemia

(2.9%) (G3/4: 0.2%)

Dehydration (2.8 %) (G3/4: 0.5%)

Hyperglycaemia

Hypophosphataemia
    
Psychiatric disorders
   Insomnia

Depression
    
Nervous system disorders
 Peripheral neuropathyc (35.6%) (G3/4: 7.6%)

Headache (17.2%) (G3/4: 0.8%)
 Dysgeusia

Dizziness (7.9%) (G3/4: 0.5%)

Hypoaesthesia

Lethargy

Neurotoxicity
    
Eye disorders
   Lacrimation increased

(6.0%) (G3/4: 0.1%)

Conjunctivitis
    
Ear and labyrinth disorders
   Vertigo
 Tinnitus
  
Cardiac disorders
   Tachycardia
    
Vascular disorders
   Hot flush
 Deep vein thrombosis

Pulmonary embolism
  
Respiratory, thoracic and mediastinal disorders
 Dyspnoea (13.9%)a (G3/4: 3.1%)

Cough (13.6%)

(G3/4: 0.6%)
 Oropharyngeal pain

Epistaxis

Rhinorrhoea
   Interstitial lung disease
 
Gastrointestinal disorders
 Nausea (33.8%)

(G3/4: 1.1%)

Constipation (19.6%)

(G3/4: 0.6%)

Diarrhoea (17.9%) (G3/4: 0.8%)

Vomiting (17.6%) (G3/4: 0.9%)
 Abdominal pain

Stomatitis (9.3%) (G3/4: 0.8%)

Dry mouth

Dyspepsia (5.9%) (G3/4: 0.2%)

Gastrooesophageal reflux disease

Mouth ulceration

Abdominal distension
   Pancreatitisb
 
Hepatobiliary disorders
   Alanine aminotransferase increased (7.6%) (G3/4: 2.1%)d

Aspartate aminotransferase increased (7.4%) (G3/4: 1.5%)

Gamma glutamyl transferase increased (1.8%) (G3/4: 0.9%)

Hyperbilirubinaemia (1.5%) (G3/4: 0.3%)
 Hepatotoxicity (1.0%) (G3/4: 0.6%)
  
Skin and subcutaneous tissue disorders
 Alopecia
 Rash

Pruritus (3.9%)

(G3/4: 0.1%)

Nail disorder

Night sweats

Dry skin

Erythema

Hyperhidrosis
 Palmar plantar erythrodysaesthesia
 Angioedema
 
Musculoskeletal and connective tissue disorders
 Arthralgia and myalgia (19.4%) (G3/4: 1.1%)

Back pain (13.0%) (G3/4:1.5%)

Pain in extremity (10.0%) (G3/4: 0.7%)
 Bone pain ( 9.6%) (G3/4: 1.7%)

Muscle spasms (5.1%) (G3/4: 0.1%)

Musculoskeletal pain and musculoskeletal chest pain

Muscular weakness
    
Renal and urinary disorders
   Dysuria
 Haematuria

Proteinuria

Renal failure
  
General disorders and administration site conditions
 Fatigue/Asthenia (47.9%) (G3/4 : 7.8%)

Pyrexia (20.4%)

(G3/4: 0.6%)
 Mucosal Inflammation (8.3%) (G3/4: 1.1%)d

Peripheral oedema

Pain

Chills

Chest Pain

Influenza like illness
    
Investigations
 Weight decrea