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s, respiratory tract disorders, asthmarare: acute respiratory distress syndromeGastrointestinal disorders:very common: diarrhoea, nauseacommon: gastrointestinal inflammatory conditions, gastrointestinal ulceration and perforation, gastrointestinal haemorrhages, stomatitis and ulceration, ascites, vomiting, gastrointestinal and abdominal pains, dyspeptic signs and symptoms, constipation, flatulence, bloating and distension, loose stools, gastrointestinal signs and symptomsuncommon: ileus paralytic, peritonitis, acute and chronic pancreatitis, blood amylase increased, gastrooesophageal reflux disease, impaired gastric emptyingrare: subileus, pancreatic pseudocystHepatobiliary disorders:common: hepatic enzymes and function abnormalities, cholestasis and jaundice, hepatocellular damage and hepatitis, cholangitisrare: hepatitic artery thrombosis, venoocclusive liver diseasevery rare: hepatic failure, bile duct stenosisSkin and subcutaneous tissue disorders:common: pruritus, rash, alopecias, acne, sweating increaseduncommon: dermatitis, photosensitivityrare: toxic epidermal necrolysis (Lyell's syndrome)very rare: Stevens Johnson syndromeMusculoskeletal and connective tissue disorders:common: arthralgia, muscle cramps, pain in limb, back painuncommon: joint disordersRenal and urinary disorders:very common: renal impairmentcommon: renal failure, renal failure acute, oliguria, renal tubular necrosis, nephropathy toxic, urinary abnormalities, bladder and urethral symptomsuncommon: anuria, haemolytic uraemic syndromevery rare: nephropathy, cystitis haemorrhagicReproductive system and breast disorders:uncommon: dysmenorrhoea and uterine bleedingGeneral disorders and administration site conditions:common: asthenic conditions, febrile disorders, oedema, pain and discomfort, blood alkaline phosphatase increased, weight increased, body temperature perception disturbeduncommon: multi-organ failure, influenza like illness, temperature intolerance, chest pressure sensation, feeling jittery, feeling abnormal, blood lactate dehydrogenase increased, weight decreasedrare: thirst, fall, chest tightness, mobility decreased, ulcervery rare: fat tissue increasedInjury, poisoning and procedural complications:common: primary graft dysfunctionMedication errors, including inadvertent, unintentional or unsupervised substitution of immediate- or prolonged-release tacrolimus formulations, have been observed. A number of associated cases of transplant rejection have been reported (frequency cannot be estimated from available data).
Manufacturer
Sandoz Limited
Drug Availability
POM – Prescription Only Medicine
Updated
02 July 2010
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