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Adoport 0.5, 1.0 and 5.0 mg Capsules(八)
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sive agents, patients receiving tacrolimus are frequently at increased risk for infections (viral, bacterial, fungal, protozoal). The course of pre-existing infections may be aggravated. Both generalised and localised infections can occur.Cases of BK virus associated nephropathy, as well as cases of JC virus associated progressive multifocal leukoencephalopathy (PML), have been reported in patients treated with immunosuppressants, including tacrolimus.Neoplasms benign, malignant and unspecified (including cysts and polyps)Patients receiving immunosuppressive therapy are at increased risk of developing malignancies. Benign as well as malignant neoplasms including EBV-associated lymphoproliferative disorders and skin malignancies have been reported in association with tacrolimus treatment.Blood and lymphatic system disorders:common: anaemia, leukopenia, thrombocytopenia, leukocytosis, red blood cell analyses abnormaluncommon: coagulopathies, coagulation and bleeding analyses abnormal, pancytopenia, neutropeniarare: thrombotic thrombocytopenic purpura, hypo-prothrombinaemiaImmune system disorders:Allergic and anaphylactoid reactions have been observed in patients receiving tacrolimus.Endocrine disorders:rare: hirsutismMetabolism and nutrition disorders:very common: hyperglycaemic conditions, diabetes mellitus, hyperkalaemiacommon: hypomagnesaemia, hypophosphataemia, hypokalaemia, hypocalcaemia, hyponatraemia, fluid overload, hyperuricaemia, appetite decreased, anorexia, metabolic acidoses, hyperlipidaemia, hypercholesterolaemia, hypertriglyceridaemia, other electrolyte abnormalitiesuncommon: dehydration, hypoproteinaemia, hyperphosphataemia, hypoglycaemiaPsychiatric disorders:very common: insomniacommon: anxiety symptoms, confusion and disorientation, depression, depressed mood, mood disorders and disturbances, nightmare, hallucination, mental disordersuncommon: psychotic disorderNervous system disorders:very common: tremor, headachecommon: seizures, disturbances in consciousness, paraesthesias and dysaesthesias, peripheral neuropathies, dizziness, writing impaired, nervous system disordersuncommon: coma, central nervous system haemorrhages and cerebrovascular accidents, paralysis and paresis, encephalopathy, speech and language abnormalities, amnesiarare: hypertoniavery rare: myastheniaEye disorders:common: vision blurred, photophobia, eye disordersuncommon: cataractrare: blindnessEar and labyrinth disorders:common: tinnitusuncommon: hypoacusisrare: deafness neurosensoryvery rare: hearing impairedCardiac disorders:common: ischaemic coronary artery disorders, tachycardiauncommon: ventricular arrhythmias and cardiac arrest, heart failures, cardiomyopathies, ventricular hypertrophy, supraventricular arrhythmias, palpitations, ECG investigations abnormal, heart rate and pulse investigations abnormalrare: pericardial effusionvery rare: echocardiogram abnormalVascular disorders:very common: hypertensioncommon: haemorrhage, thrombembolic and ischaemic events, peripheral vascular disorders, vascular hypotensive disordersuncommon: infarction, venous thrombosis deep limb, shockRespiratory, thoracic and mediastinal disorders:common: dyspnoea, parenchymal lung disorders, pleural effusion, pharyngitis, cough, nasal congestion and inflammationsuncommon: respiratory failure |
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