eoral®, and Sandimune®).
Tacrolimus capsules are not for use with a medicine called sirolimus (Rapamune®) in people who have had a liver or heart transplants.
It is not known if Tacrolimus capsules are safe and effective when used with sirolimus in people who have had kidney transplants.
It is not known if Tacrolimus capsules are safe and effective in children who have had a kidney or heart transplants.
Who should not take Tacrolimus capsules?
Do not take Tacrolimus capsules if you are allergic to Tacrolimus or any of the ingredients in Tacrolimus capsules. See the end of this leaflet for a complete list of ingredients in Tacrolimus capsules.
What should I tell my doctor before taking Tacrolimus capsules?
Before you take Tacrolimus capsules, tell your doctor if you:
•plan to receive any live vaccines
•have or have had liver, kidney or heart problems
•are pregnant or plan to become pregnant. Tacrolimus capsules may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
•Are breastfeeding or plan to breastfeed. Tacrolimus capsules can pass into your breast milk. You and your doctor should decide if you will take Tacrolimus capsules or breastfeed. You should not do both.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Especially tell your doctor if you take:
•cyclosporine (Gengraf®, Neoral®, and Sandimune®)
•sirolimus (Rapamune®)
•nelfinavir (Viracept®)
•telaprevir (IncivekTM)
•boceprevir (VictrelisTM)
•amiodarone (CordaroneTM, NexteroneTM, PaceroneTM)
Ask your doctor or pharmacist if you are not sure if you take any of the medicines listed above. Tacrolimus capsules may affect the way other medicines work, and other medicines may affect how Tacrolimus capsules works. Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.
How should I take Tacrolimus capsules?
•Take Tacrolimus capsules exactly as your doctor tells you to take it.
•Your doctor will tell you how many Tacrolimus capsules to take and when to take them.
•Your doctor may change your Tacrolimus capsules dose if needed. Do not stop taking or change your dose of Tacrolimus capsules without talking to your doctor.
•Take Tacrolimus capsules with or without food.
•Take Tacrolimus capsules the same way everyday. For example, if you choose to take Tacrolimus capsules with food, you should always take Tacrolimus capsules with food.
•Take Tacrolimus capsules at the same time each day. For example, if you take your first dose at 7: 00 a.m. you should take your second dose at 7:00 p.m
◦Taking Tacrolimus capsules at the same time each day helps to keep enough medicine in your body to give your transplanted organ the around-the-clock medicine it needs.
•Do not eat grapefruit or drink grapefruit juice while taking Tacrolimus capsules.
•If you take too much Tacrolimus capsules, call your doctor or go to the nearest hospital emergency room right away.
What should I avoid while taking Tacrolimus capsules?
•While you take Tacrolimus capsules you should not receive any live vaccines such as:
◦flu vaccine through your nose
◦measles
◦mumps
◦rubella
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