e to immunosuppression and to contact their physician if they develop any symptoms of infection [see Warnings and Precautions (5.3, 5.4, 5.5)].
17.4 New Onset Diabetes After Transplant
Inform patients that Tacrolimus can cause diabetes mellitus and should be advised to contact their physician if they develop frequent urination, increased thirst or hunger [see Warnings and Precautions (5.6)].
17.5 Nephrotoxicity
Inform patients that Tacrolimus can have toxic effects on the kidney that should be monitored. Advise patients to attend all visits and complete all blood tests ordered by their medical team [see Warnings and Precautions (5.7)].
17.6 Neurotoxicity
Inform patients that they are at risk of developing adverse neurologic effects including seizure, altered mental status, and tremor. Advise patients to contact their physician should they develop vision changes, deliriums, or tremors [see Warnings and Precautions (5.8)].
17.7 Hyperkalemia
Inform patients that Tacrolimus can cause hyperkalemia. Monitoring of potassium levels may be necessary, especially with concomitant use of other drugs known to cause hyperkalemia [see Warnings and Precautions (5.9)].
17.8 Hypertension
Inform patients that Tacrolimus can cause high blood pressure which may require treatment with anti-hypertensive therapy [see Warnings and Precautions (5.10)].
17.9 Drug Interactions
Instruct patients to tell their health care providers when they start or stop taking all the medicines, including prescription medicines and non-prescription medicines, natural or herbal remedies, nutritional supplements and vitamins [see Drug Interactions (7)].
17.10 Pregnant Women and Nursing Mothers
Instruct patients to tell their healthcare provider if they plan to become pregnant or breast-feed their infant [see Use in Specific Populations (8.1,8.3)]
17.11 Immunizations
Inform patients that Tacrolimus can interfere with the usual response to immunizations and that they should avoid live vaccines [see Warnings and Precautions (5.15)].
Patient Information
Tacrolimus Capsules USP
Read this Patient Information before you start taking Tacrolimus capsules and each time you get a refill. There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment.
What is the most important information I should know about Tacrolimus capsules?
Tacrolimus capsules can cause serious side effects, including:
1. Increased risk of cancer. People who take Tacrolimus capsules have an increased risk of getting some kinds of cancer, including skin and lymph gland cancer (lymphoma).
2. Increased risk of infection. Tacrolimus capsules is a medicine that affects your immune system. Tacrolimus capsules can lower the ability of your immune system to fight infections. Serious infections can happen in people receiving Tacrolimus capsules that can cause death. Call your doctor right away if you have symptoms of an infection such as:
•fevers
•weats or chills
•cough or flu-like symptoms
•muscle aches
•warm, red, or painful areas on your skin
What are Tacrolimus capsules?
Tacrolimus capsules are a prescription medicine used with other medicines to help prevent organ rejection in people who have had a kidney, liver, or heart transplant and Tacrolimus capsules are not for use with medicines called cyclosporines (Gengraf®, N |
