given to a child under the age of 2 years.
Safety and effectiveness in children younger than 2 years has not been established.
Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
If it has expired or is damaged, return it to your pharmacist for disposal.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any foods, preservatives or dyes or any other medicines, especially antifungal medicines such as itraconazole (Sporanox), fluconazole (Diflucan) or ketoconazole (Nizoral) (not all brands given).
Tell your doctor if you have or have had any of the following medical conditions:
heart problems
any problems affecting your kidneys
any problems affecting your liver. If you have liver disease your doctor may prescribe a lower dose
recent chemotherapy or stem cell transplant.
Tell your doctor if you are pregnant or plan to become pregnant.
VFEND should not be taken during pregnancy, unless indicated by your doctor. Effective contraception should be used in women of childbearing potential. Your doctor can discuss with you the risks and benefits involved.
Tell your doctor if you are breast-feeding.
VFEND should not be taken whilst breastfeeding, unless indicated by your doctor. It is not known if the active ingredient voriconazole passes into breast milk. Your doctor can discuss with you the risks and benefits involved.
If you have not told your doctor about any of the above, tell your doctor before you start taking VFEND.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you get without a prescription from a pharmacy, supermarket or health food shop.
Some medicines should not be taken with VFEND. These include (not all brands given):
pimozide (e.g. Orap), a medicine used to treat mental illness
quinidine (e.g. Kinidin Durules), a medicine for irregular heartbeat
rifampicin (e.g. Rifadin, Rimycin), a medicine used to treat tuberculosis
carbamazepine (e.g. Tegretol, Teril), a medicine used to treat seizures
long-acting barbiturates such as phenobarbitone, medicines used to treat severe insomnia and seizures
ergotamine (e.g. Cafergot) or dihydroergotamine (e.g. Dihydergot), medicines used to treat migraine
sirolimus (e.g. Rapamune) a medicine used in transplant patients
ritonavir (e.g. Norvir, Kaletra) (a medicine used to treat HIV infection) in doses of 400 mg or more twice a day
St John's wort, (a herbal medicine).
Some medicines and VFEND may interfere with each other. These include (not all brands given):
efavirenz (Stocrin), a medicine used to treat HIV infection
ritonavir (Norvir, Kaletra) (a medicine used to treat HIV infection) in doses of 100 mg twice a day
warfarin (e.g. Marevan, Coumadin), a medicine used to stop blood clots
phenytoin (e.g. Dilantin), a medicine used to treat epilepsy
cyclosporin (e.g. Sandimmun, Neoral), a medicine used to prevent organ transplant rejection or to treat certain problems with the immune system
sulphonylureas, medicines used to treat diabetes such as glibenclamide, gliclazide and glipizide (e.g. Daonil, Diamicron, Minidiab)
rifabutin (e.g. Mycobutin), an antibiotic
theophylline (eg Nuelin), a medicine used to treat asthma
benzodiazepines (e.g. Valium), medicines used to treat insomnia or anxiety
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