INLYTA may cause serious side effects, including:
 • High blood pressure (hypertension). Your doctor should check your blood pressure regularly during treatment with INLYTA. If you develop blood pressure problems, your doctor may prescribe medicine to treat your high blood pressure, lower your dose, or stop your treatment with INLYTA.
 • Thyroid gland problems. Your doctor should do blood tests to check your thyroid gland function before and during your treatment with INLYTA. Tell your doctor if you have any of the following symptoms during your treatment with INLYTA: ◦tiredness that worsens or that does not go away
 ◦feeling hot or cold
 ◦your voice deepens
 ◦weight gain or weight loss
 ◦hair loss
 ◦muscle cramps and aches
 
• Problem with blood clots in your veins or arteries. Get emergency help and call your doctor if you get any of the following symptoms: ◦chest pain or pressure
 ◦pain in your arms, back, neck or jaw
 ◦shortness of breath
 ◦numbness or weakness on one side of your body
 ◦trouble talking
 ◦headache
 ◦vision changes
 
• Bleeding. INLYTA can cause bleeding which can be serious, and sometimes lead to death. Call your doctor or get medical help if you develop any bleeding, including: ◦unexpected bleeding or bleeding that lasts a long time, such as:
 ◦unusual bleeding from the gums
 ◦menstrual bleeding or vaginal bleeding that is heavier than normal
 ◦bleeding that is severe or you cannot control
 ◦pink or brown urine
 ◦red or black stools (looks like tar)
 ◦bruises that happen without a known cause or get larger
 ◦cough up blood or blood clots
 ◦vomit blood or your vomit looks like "coffee grounds"
 ◦unexpected pain, swelling, or joint pain
 ◦headaches, feeling dizzy or weak
 
• Tear in your stomach or intestinal wall (perforation). Get medical help right away if you get the following symptoms: ◦severe stomach (abdominal) pain or stomach pain that does not go away
 ◦vomit blood
 ◦red or black stools

• Reversible Posterior Leukoencephalopathy Syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome (RPLS) can happen while taking INLYTA. Call your doctor right away if you get: ◦headache
 ◦seizures
 ◦weakness
 ◦confusion
 ◦high blood pressure
 ◦blindness or change in vision
◦problems thinking
 
• Increased protein in your urine. Your doctor should check your urine for protein before and during your treatment with INLYTA. If you develop protein in your urine, your doctor may decrease your dose of INLYTA or stop your treatment.
 • Change in liver function. Your doctor should do blood tests before and during your treatment with INLYTA to check your liver function.
 
The most common side ef