品名：盐酸吡格列酮盐酸二甲双胍缓释片
剂型与规格：缓释包衣片剂，15mg/1000mg；30mg/1000mg
适应症：Ⅱ型糖尿病
原研单位及国外上市时间：武田制药株式会社研发，2009年5月获得FDA批准上市，商品名ACTOPLUS MET® XR
关于本品：
盐酸吡格列酮为噻唑烷二酮类抗糖尿病药物，属胰岛素增敏剂，作用机制与胰岛素的存在有关，可减少外周组织和肝脏的胰岛素抵抗，增加依赖胰岛素的葡萄糖的处理，并减少肝糖的输出。与磺酰脲类不同，本品不是一个胰岛素促分泌药。其作用机制是高选择性的激动过氧化物酶小体生长因子活化受体-γ[PPAR-γ]，PPAR-γ的活化可调节许多控制葡萄糖及脂类代谢的胰岛素相关基因的转录。实验表明，本品可减少胰岛素抵抗的高血糖、高胰岛素因症及高三酰甘油。本品引起的代谢变化导致了依赖胰岛素的组织应答的增加。由于本品提高了循环胰岛素的作用（即降低胰岛素抵抗），因此它不能降低缺乏内源性胰岛素的血糖。
复方产品将两种广泛使用的糖尿病治疗药盐酸吡格列酮和盐酸二甲双胍制成单一片剂。盐酸吡格列酮直接作用于胰岛素耐受性，盐酸二甲双胍主要减少肝脏产生的葡萄糖量。两种药物结合有助于控制Ⅱ型糖尿病患者的血糖浓度。

Active ingredient: metformin and pioglitazone.
Generic ActoPlus Met is used for treating type 2 diabetes.В  It is used along with diet and exercise. It works by decreasing the amount of sugar the liver produces and the intestines absorb.

What is this medicine?

METFORMIN; PIOGLITAZONE helps to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.
What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

become easily dehydrated
diabetic ketoacidosis
heart disease
if you frequently drink alcohol containing drinks
kidney disease
liver disease
polycystic ovary syndrome
serious infection or injury
swelling of the arms, legs, or feet
undergoing surgery or certain x-ray procedures with injectable contrast agents
vomiting
an unusual or allergic reaction to metformin, pioglitazone, medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?

Take this medicine by mouth with a glass of water. Take this medicine with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor’s advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

dofetilide
gatifloxacin
certain contrast medicines given before X-rays, CT scans, MRI, or other procedures
This medicine may also interact with the following medications: