Expected:

↑ Sofosbuvir (TPV)

↔ Sofosbuvir (BOC)

↔ GS-331007 (TPV or BOC)
 No drug-drug interaction data exists regarding the co-administration of Sovaldi with boceprevir or telaprevir.
 
NARCOTIC ANALGESICS
 
Methadonef

(Methadone maintenance therapy [30 to 130 mg/daily])
 R-methadone

↔ Cmax 0.99 (0.85, 1.16)

↔ AUC 1.01 (0.85, 1.21)

↔ Cmin 0.94 (0.77, 1.14)

S-methadone

↔ Cmax 0.95 (0.79, 1.13)

↔ AUC 0.95 (0.77, 1.17)

↔ Cmin 0.95 (0.74, 1.22)

Sofosbuvir

↓ Cmax 0.95c (0.68, 1.33)

↑ AUC 1.30c (1.00, 1.69)

Cmin (NA)

GS-331007

↓ Cmax 0.73c (0.65, 0.83)

↔ AUC 1.04c (0.89, 1.22)

Cmin (NA)
 No dose adjustment of sofosbuvir or methadone is required when sofosbuvir and methadone are used concomitantly.
 
IMMUNOSUPPRESSANTS
 
Ciclosporine

(600 mg single dose)
 Ciclosporin

↔ Cmax 1.06 (0.94, 1.18)

↔ AUC 0.98 (0.85, 1.14)

Cmin (NA)

Sofosbuvir

↑ Cmax 2.54 (1.87, 3.45)

↑ AUC 4.53 (3.26, 6.30)

Cmin (NA)

GS-331007

↓ Cmax 0.60 (0.53, 0.69)

↔ AUC 1.04 (0.90, 1.20)

Cmin (NA)
 No dose adjustment of sofosbuvir or ciclosporin is required when sofosbuvir and ciclosporin are used concomitantly.
 
Tacrolimuse

(5 mg single dose)
 Tacrolimus

↓ Cmax 0.73 (0.59, 0.90)

↔ AUC 1.09 (0.84, 1.40)

Cmin (NA)

Sofosbuvir

↓ Cmax 0.97 (0.65, 1.43)

↑ AUC 1.13 (0.81, 1.57)

Cmin (NA)

GS-331007

↔ Cmax 0.97 (0.83, 1.14)

↔ AUC 1.00 (0.87, 1.13)

Cmin (NA)
 No dose adjustment of sofosbuvir or tacrolimus is required when sofosbuvir and tacrolimus are used concomitantly.
 
HIV ANTIVIRAL AGENTS: REVERSE TRANSCRIPTASE INHIBITORS
 
Efavirenzf

(600 mg once daily)d
 Efavirenz

↔ Cmax 0.95 (0.85, 1.06)

↔ AUC 0.96 (0.91, 1.03)

↔ Cmin 0.96 (0.93, 0.98)

Sofosbuvir

↓ Cmax 0.81 (0.60, 1.10)

↔ AUC 0.94 (0.76, 1.16)

Cmin (NA)

GS-331007

↓ Cmax 0.77 (0.70, 0.84)

↔ AUC 0.84 (0.76, 0.92)

Cmin (NA)
 No dose adjustment of sofosbuvir or efavirenz is required when sofosbuvir and efavirenz are used concomitantly.
 
Emtricitabinef

(200 mg once daily)d
 Emtricitabine

↔ Cmax 0.97 (0.88, 1.07)

↔ AUC 0.99 (0.94, 1.05)

↔ Cmin 1.04 (0.98, 1.11)

Sofosbuvir

↓ Cmax 0.81 (0.60, 1.10)

↔ AUC 0.94 (0.76, 1.16)

Cmin (NA)

GS-331007

↓ Cmax 0.77 (0.70, 0.84)

↔ AUC 0.84 (0.76, 0.92)

Cmin (NA)
 No dose adjustment of sofosbuvir or emtricitabine is required when sofosbuvir and emtricitabine are used concomitantly.
 
Tenofovir disoproxil fumaratef

(300 mg once daily)d
 Tenofovir

↑ Cmax 1.25 (1.08, 1.45)

↔ AUC 0.98 (0.91, 1.05)

↔ Cmin 0.99 (0.91, 1.07)

Sofosbuvir

↓ Cmax 0.81 (0.60, 1.10)

↔ AUC 0.94 (0.76, 1.16)

Cmin (NA)

GS-331007

↓ Cmax 0.77 (0.70, 0.84)

↔ AUC 0.84 (0.76, 0.92)

Cmin (NA)
 No dose adjustment of sofosbuvir or ten