junctivitis, dry eye, blurred vision
Uncommon:
Eye irritation, eye pain, orbital oedema, scleral haemorrhage, retinal haemorrhage, blepharitis, macular oedema
Rare:
Cataract, glaucoma, papilloedema
Ear and labyrinth disorders
Uncommon:
Vertigo, tinnitus, hearing loss
Cardiac disorders
Uncommon:
Palpitations, tachycardia, cardiac failure congestive3, pulmonary oedema
Rare:
Arrhythmia, atrial fibrillation, cardiac arrest, myocardial infarction, angina pectoris, pericardial effusion
Vascular disorders4
Common:
Flushing, haemorrhage
Uncommon:
Hypertension, haematoma, subdural haematoma, peripheral coldness, hypotension, Raynaud's phenomenon
Respiratory, thoracic and mediastinal disorders
Common:
Dyspnoea, epistaxis, cough
Uncommon:
Pleural effusion5, pharyngolaryngeal pain, pharyngitis
Rare:
Pleuritic pain, pulmonary fibrosis, pulmonary hypertension, pulmonary haemorrhage
Gastrointestinal disorders
Very common:
Nausea, diarrhoea, vomiting, dyspepsia, abdominal pain6
Common:
Flatulence, abdominal distension, gastro-oesophageal reflux, constipation, dry mouth, gastritis
Uncommon:
Stomatitis, mouth ulceration, gastrointestinal haemorrhage7, eructation, melaena, oesophagitis, ascites, gastric ulcer, haematemesis, cheilitis, dysphagia, pancreatitis
Rare:
Colitis, ileus, inflammatory bowel disease
Hepatobiliary disorders
Common:
Increased hepatic enzymes
Uncommon:
Hyperbilirubinaemia, hepatitis, jaundice
Rare:
Hepatic failure8, hepatic necrosis
Skin and subcutaneous tissue disorders
Very common:
Periorbital oedema, dermatitis/eczema/rash
Common:
Pruritus, face oedema, dry skin, erythema, alopecia, night sweats, photosensitivity reaction
Uncommon:
Rash pustular, contusion, sweating increased, urticaria, ecchymosis, increased tendency to bruise, hypotrichosis, skin hypopigmentation, dermatitis exfoliative, onychoclasis, folliculitis, petechiae, psoriasis, purpura, skin hyperpigmentation, bullous eruptions
Rare:
Acute febrile neutrophilic dermatosis (Sweet's syndrome), nail discolouration, angioneurotic oedema, rash vesicular, erythema multiforme, leucocytoclastic vasculitis, Stevens-Johnson syndrome, acute generalised exanthematous pustulosis (AGEP)
Musculoskeletal and connective tissue disorders
Very common:
Muscle spasm and cramps, musculoskeletal pain including myalgia, arthralgia, bone pain9
Common:
Joint swelling
Uncommon:
Joint and muscle stiffness
Rare:
Muscular weakness, arthritis, rhabdomyolysis/myopathy
Renal and urinary disorders
Uncommon:
Renal pain, haematuria, renal failure acute, urinary frequency increased
Reproductive system and breast disorders
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