(simvastatin) because of possible serious reactions. There is also an increased risk of drug interactions between NORVIR and Lipitor® (atorvastatin); talk to your doctor before you take any of these cholesterol-lowering medicines with NORVIR.
Medicines That May Require Dosage Adjustments
It is possible that your doctor may need to increase or decrease the dose of other medicines when you are also taking NORVIR. Remember to tell your doctor all medicines you are taking or plan to take.
The following medicines require dose reduction if taken with NORVIR:
If you are taking PDE5 inhibitors for erectile dysfunction including Viagra® (sildenafil), Cialis® (tadalafil), or Levitra® (vardenafil), your doctor may lower your dose of these medications. You should not use sildenafil (Revatio®) with NORVIR if you are being treated for pulmonary arterial hypertension. If you are taking AdcircaTM (tadalafil) for pulmonary arterial hypertension, your doctor may change your dose of this medicine.
Before you take Viagra®, Cialis® or Levitra® with NORVIR, talk to your doctor about possible drug interactions and side effects. If you take these medications with NORVIR you may be at risk of side effects such as low blood pressure, visual changes, and penile erection lasting more than 4 hours. If an erection lasts longer than 4 hours, you should get medical help immediately to avoid permanent damage to your penis. Your doctor can explain these symptoms to you.
If you are taking Oral contraceptives ("the pill") or the contraceptive patch to prevent pregnancy, you should use a different type of contraception since NORVIR may reduce the effectiveness of oral or patch contraceptives.
If you are taking Mycobutin® (rifabutin), your doctor will lower the dose of Mycobutin.
If you are taking Colcrys® (colchicine), your doctor will tell you what dose to use.
If you are taking Tracleer® (bosentan), your doctor will tell you what dose to use.
Other Special Considerations:
NORVIR oral solution contains alcohol. Talk with your doctor if you are taking or planning to take metronidazole or disulfiram. Severe nausea and vomiting can occur.
If you are taking both didanosine (Videx) and NORVIR:
Didanosine and NORVIR should be separated by at least 2.5 hours.
Rifampin, also known as Rimactane®, Rifadin®, Rifater®, or Rifamate®, may reduce blood levels of NORVIR. Be sure to tell your doctor if you are taking rifampin.
If you are taking or before you begin using inhaled Flonase® (fluticasone propionate), talk to your doctor about problems these two medicines may cause when taken together. Your doctor may choose not to keep you on inhaled Flonase®.
Rifampin and saquinavir should not be taken with NORVIR. Be sure to tell your doctor if you are taking rifampin and saquinavir.
If you are taking or before you begin using Serevent® (salmeterol) and NORVIR, talk to your doctor about problems these medicines may cause when taken together. Your doctor may choose not to keep you on Serevent® (salmeterol).
If you are taking or before you begin using Advair® (salmeterol in combination with fluticasone propionate) and NORVIR, talk to your doctor about problems these two medicines may cause when taken together. Your doctor may choose not to keep you on Advair® (salmeterol in combination with fluticasone propionate).
What Are the Possible Side Effects of NORVIR?
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