Pediatric Dosage Guidelines1 Body Surface Area (m2) Twice Daily Dose
250 mg/m2 Twice Daily Dose
300 mg/m2 Twice Daily Dose
350 mg/m2 Twice Daily Dose
400 mg/m2
0.20 0.6 mL (50 mg) 0.75 mL (60 mg) 0.9 mL (70 mg) 1.0 mL (80 mg)
0.25 0.8 mL (62.5 mg) 0.9 mL (75 mg) 1.1 mL (87.5 mg) 1.25 mL (100 mg)
0.50 1.6 mL (125 mg) 1.9 mL (150 mg) 2.2 mL (175 mg) 2.5 mL (200 mg)
0.75 2.3 mL (187.5 mg) 2.8 mL (225 mg) 3.3 mL (262.5 mg) 3.75 mL (300 mg)
1.00 3.1 mL (250 mg) 3.75 mL (300 mg) 4.4 mL (350 mg) 5 mL (400 mg)
1.25 3.9 mL (312.5 mg) 4.7 mL (375 mg) 5.5 mL (437.5 mg) 6.25 mL (500 mg)
1.50 4.7 mL (375 mg) 5.6 mL (450 mg) 6.6 mL (525 mg) 7.5 mL (600 mg)

Body surface area (BSA) can be calculated as follows:

General Dosing Guidelines
Patients should be aware that frequently observed adverse events, such as mild to moderate gastrointestinal disturbances and paraesthesias, may diminish as therapy is continued. In addition, patients initiating combination regimens with NORVIR and reverse transcriptase inhibitors may improve gastrointestinal tolerance by initiating NORVIR alone and subsequently adding reverse transcriptase inhibitors before completing two weeks of NORVIR monotherapy.

HOW SUPPLIED
NORVIR (ritonavir capsules) soft gelatin are white capsules imprinted with the corporate Abbott “A” logo, 100 and the Abbo-Code DS, available in the following package size:

Bottles of 120 capsules each (NDC 0074-6633-22).

Bottles of 30 capsules each (NDC 0074-6633-30).

Recommended Storage
Store soft gelatin capsules in the refrigerator between 2°-8°C (36°-46°F) until dispensed. Refrigeration of NORVIR soft gelatin capsules by the patient is recommended, but not required if used within 30 days and stored below 25°C (77°F). Protect from light. Avoid exposure to excessive heat.

NORVIR (ritonavir oral solution) is an orange-colored liquid, supplied in amber-colored, multi-dose bottles containing 600 mg ritonavir per 7.5 mL marked dosage cup (80mg/mL) in the following size:

240 mL bottles (NDC 0074-1940-63).

Recommended Storage
Store NORVIR oral solution at room temperature 20°-25°C (68°-77°F). Do not refrigerate. Shake well before each use. Use by product expiration date.

Product should be stored and dispensed in the original container.

Avoid exposure to excessive heat. Keep cap tightly closed.

REFERENCES
Sewester CS. Calculations. In: Drug Facts and Comparisons. St. Louis, MO: J.B. Lippincott Co; January, 1997:xix.
Bertz RJ and Granneman GR. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin Pharmacokinet 1997; 32(3):210-258.
Abbott Laboratories

North Chicago, IL 60064, U.S.A.

Rev. 04/2010

NORVIR®
(ritonavir capsules) Soft Gelatin
ALERT: Find out about medicines that should NOT be taken with NORVIR. Please also read the section "MEDICINES YOU SHOULD NOT TAKE WITH NORVIR."

Patient Information
NORVIR® (NOR - VEER)

Generic name: ritonavir (rit-ON-uh-veer)

Please read this leaflet carefully before you start taking NORVIR. Also, read it each time you get your NORVIR prescription refilled, just in case something has chang