s, vitamins, and herbal supplements.
Especially tell your healthcare provider if you take:
•rifabutin or phenytoin. If you are taking these medicines, you should not take Noxafil delayed-release tablets or Noxafil oral suspension.
•cimetidine or esomeprazole. If you are taking these medicines, you should not take Noxafil oral suspension.
Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.
Know the medicines you take. Keep a list of them with you to show your healthcare provider or pharmacist when you get a new medicine.
How should I take Noxafil?
•Take Noxafil exactly as your healthcare provider tells you to take it.
•Your healthcare provider will tell you how much Noxafil to take and when to take it.
•Take Noxafil for as long as your healthcare provider tells you to take it.
•If you take too much Noxafil, call your healthcare provider or go to the nearest hospital emergency room right away.
• Noxafil Delayed-Release Tablets: ◦Take Noxafil delayed-release tablets with food.
◦Take Noxafil delayed-release tablets whole. Do not break, crush, dissolve or chew Noxafil delayed-release tablets before swallowing. If you cannot swallow Noxafil delayed-release tablets whole, tell your healthcare provider. You may need a different medicine.
◦If you miss a dose, take it as soon as you remember and then take your next scheduled dose at its regular time. If, however, it is within 12 hours of your next dose, do not take the missed dose. Skip the missed dose and go back to your regular schedule. Do not double your next dose or take more than your prescribed dose.
• Noxafil Oral Suspension: ◦Shake Noxafil oral suspension well before use.
◦Take each dose of Noxafil oral suspension during or within 20 minutes after a full meal. If you cannot eat a full meal, take each dose of Noxafil oral suspension with a liquid nutritional supplement or an acidic carbonated beverage, like ginger ale.
◦A measured dosing spoon comes with your Noxafil oral suspension and is marked for doses of 2.5 mL and 5 mL. See Figure A.
Image of Figure 1
Figure A
◦Rinse the spoon with water after each dose of Noxafil oral suspension and before you store it away.
Follow your doctor's instructions on how much Noxafil you should take and when.
What are the possible side effects of Noxafil?
Noxafil may cause serious side effects, including:
• drug interactions with cyclosporine or tacrolimus. If you take Noxafil with cyclosporine or tacrolimus, your blood levels of cyclosporine or tacrolimus may increase. Serious side effects can happen in your kidney or brain if you have high levels of cyclosporine or tacrolimus in your blood. Your healthcare provider should do blood tests to check your levels of cyclosporine or tacrolimus if you are taking these medicines while taking Noxafil. Tell your healthcare provider right away if you have swelling in your arm or leg or shortness of breath.
• problems with the electrical system of your heart (arrhythmias and QTc pro