Patient Information
 
Noxafil® (NOX-a-fil)
(posaconazole)
delayed-release tablets
 
Noxafil® (NOX-a-fil)
(posaconazole)
 oral suspension
 
What is Noxafil?
 
Noxafil delayed-release tablets and Noxafil oral suspension are prescription medicines used to help prevent fungal infections that can spread throughout your body (invasive fungal infections). These infections are caused by fungi called Aspergillus or Candida. Noxafil is used in people who have an increased chance of getting these infections due to a weak immune system. These include people who have:
•had a hematopoietic stem cell transplantation (bone marrow transplant) with graft versus host disease
•a low white blood cell count due to chemotherapy for blood cancers (hematologic malignancy)
 
Noxafil oral suspension is also used to treat a fungal infection called "thrush" caused by Candida in your mouth or throat area. Noxafil oral suspension can be used as the first treatment for thrush, or as another treatment for thrush after itraconazole or fluconazole treatment has not worked.
 
It is not known if Noxafil is safe and effective in children under 13 years of age.
 
Who should not take Noxafil?
 
Do not take Noxafil if you:
•are allergic to posaconazole, any of the ingredients in Noxafil, or other azole antifungal medicines. See the end of this leaflet for a complete list of ingredients in Noxafil.
•are taking any of the following medicines:◦sirolimus
◦pimozide
◦quinidine
◦certain statin medicines that lower cholesterol (atorvastatin, lovastatin, simvastatin)
◦ergot alkaloids (ergotamine, dihydroergotamine)
 
Ask your healthcare provider or pharmacist if you are not sure if you are taking any of these medicines.
 
Do not start taking a new medicine without talking to your healthcare provider or pharmacist.
 
What should I tell my healthcare provider before taking Noxafil?
 
Before you take Noxafil, tell your healthcare provider if you:
•are taking certain medicines that lower your immune system like cyclosporine or tacrolimus.
•are taking certain drugs for HIV infection, such as ritonavir, atazanavir, efavirenz, or fosamprenavir. Efavirenz and fosamprenavir can cause a decrease in the Noxafil levels in your body. Efavirenz and fosamprenavir should not be taken with Noxafil.
•are taking midazolam, a hypnotic and sedative medicine.
•have or had liver problems.
•have or had kidney problems.
•have or had an abnormal heart rate or rhythm, heart problems, or blood circulation problems.
•are pregnant or plan to become pregnant. It is not known if Noxafil will harm your unborn baby.
•are breastfeeding or plan to breastfeed. It is not known if Noxafil passes into your breast milk. You and your healthcare provider should decide if you will take Noxafil or breastfeed. You should not do both.
 
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicine