Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use LINZESS for a condition for which it was not prescribed. Do not give LINZESS to other people, even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about LINZESS. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about LINZESS that is written for health professionals. For more information, go to www.LINZESS.com or call 1-800-678-1605.

What are the ingredients in LINZESS?

Active ingredient: linaclotide

Inactive ingredients: calcium chloride dihydrate, L-leucine, hypromellose, microcrystalline cellulose, gelatin, and titanium dioxide.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Issued: August 2012

LINZESS is a trademark of Ironwood Pharmaceuticals, Inc.

Distributed by:
Forest Pharmaceuticals, Inc.
Subsidiary of Forest Laboratories, Inc.
St. Louis, Missouri, 63045

Marketed by:
Forest Pharmaceuticals, Inc.
Subsidiary of Forest Laboratories, Inc.        Ironwood Pharmaceuticals, Inc.
St. Louis, Missouri, 63045                             Cambridge, MA, 02142

© Copyright 2012 Forest Laboratories, Inc.

Principal Display Panel – 145 mcg Bottle Label

Rx Only NDC 0456-1201-30
30 CAPSULES

Linzess™
(linaclotide) capsules

145 mcg / capsule

ATTENTION PHARMACIST:
Each patient is required to receive
the enclosed Medication Guide

Keep LINZESS in the original container
to protect from moisture. Do not remove
the desiccant from inside the bottle.

Principal Display Panel – 145 mcg Carton Label

Rx Only NDC 0456-1201-30
30 CAPSULES

Linzess™
(linaclotide) capsules

145 mcg / capsule

ATTENTION PHARMACIST:
Each patient is required to receive
the enclosed Medication Guide

Keep LINZESS in the original container
to protect from moisture. Do not remove
the desiccant from inside the bottle

FOREST PHARMACEUTICALS, INC.

Subsidiary of Forest Laboratories, Inc.

St. Louis, Missouri 63045

Ironwood

IRONWOD PHARMACEUTICALS

CAMBRIDGE MA 02142

Principal Display Panel – 290 mcg Bottle Label

Rx Only NDC 0456-1202-30
30 CAPSULES

Linzess™
(linaclotide) capsules

290 mcg / capsule

ATTENTION PHARMACIST:
Each patient is required to receive
the enclosed Medication Guide

Keep LINZESS in the original container
to protect from moisture. Do not remove
the desiccant from inside the bottle.

Principal Display Panel – 290 mcg Carton Label

Rx Only NDC 0456-1202-30
30 CAPSULES

Linzess™
(linaclotide) capsules

290 mcg / capsule

ATTENTION PHARMACIST:
Each patient is required to receive
the enclosed Medication Guide

Keep LINZESS in the original container
to protect from moisture. Do not remove
the desiccant from inside the bottle

FOREST PHARMACEUTICALS, INC.

Subs