atients with potentially proarrhythmic conditions.
•are pregnant, plan to become pregnant, or are nursing.
•have liver disease or develop itching, nausea or vomiting, their eyes or skin turn yellow, they feel more tired than usual or feel like they have the flu.
•have ever had an allergic reaction to other antifungal medicines such as ketoconazole, fluconazole, itraconazole, or voriconazole.
Manuf. for: Merck Sharp & Dohme Corp., a subsidiary of
MERCK & CO., INC., Whitehouse Station, NJ 08889, USA
Delayed-Release Tablets: Manuf. by: N. V. Organon, Kloosterstraat 6, 5349 AB Oss, Netherlands
Oral Suspension: Manuf. by: Patheon Inc., Whitby, Ontario, Canada L1N 5Z5
For patent information: www.merck.com/product/patent/home.html
The trademarks referenced herein are owned by their respective owners.
Copyright © 2006, 2010, 2013 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.
All rights reserved.
uspi-mk5592-mtl-1311r030
Patient Information
Noxafil® (NOX-a-fil)
(posaconazole)
delayed-release tablets
Noxafil® (NOX-a-fil)
(posaconazole)
oral suspension
What is Noxafil?
Noxafil delayed-release tablets and Noxafil oral suspension are prescription medicines used to help prevent fungal infections that can spread throughout your body (invasive fungal infections). These infections are caused by fungi called Aspergillus or Candida. Noxafil is used in people who have an increased chance of getting these infections due to a weak immune system. These include people who have:
•had a hematopoietic stem cell transplantation (bone marrow transplant) with graft versus host disease
•a low white blood cell count due to chemotherapy for blood cancers (hematologic malignancy)
Noxafil oral suspension is also used to treat a fungal infection called "thrush" caused by Candida in your mouth or throat area. Noxafil oral suspension can be used as the first treatment for thrush, or as another treatment for thrush after itraconazole or fluconazole treatment has not worked.
It is not known if Noxafil is safe and effective in children under 13 years of age.
Who should not take Noxafil?
Do not take Noxafil if you:
•are allergic to posaconazole, any of the ingredients in Noxafil, or other azole antifungal medicines. See the end of this leaflet for a complete list of ingredients in Noxafil.
•are taking any of the following medicines:◦sirolimus
◦pimozide
◦quinidine
◦certain statin medicines that lower cholesterol (atorvastatin, lovastatin, simvastatin)
◦ergot alkaloids (ergotamine, dihydroergotamine)
Ask your healthcare provider or pharmacist if you are not sure if you are taking any of these medicines.
Do not start taking a new medicine without talking to your healthcare provider or pharmacist.
What should I tell my healthcare provider before taking Noxafil?
Before you take Noxafil, tell your healthcare provider if you:
•are taking certain medicines that lower your immune system like cyclosporine or tacrolimus.
•are taking certain drugs for HIV infection, such as ritonavir, atazanavir, efavirenz, or fosamprena
