Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.

Intravenous Infusion
The infusion solution should be prepared immediately prior to use. Based on the desired dose, the appropriate vial strength(s) of INTRON A should be reconstituted with the diluent provided. Inject 1 mL Diluent (Sterile Water for Injection USP) for INTRON A into the INTRON A vial. Swirl gently to hasten complete dissolution of the powder. The appropriate INTRON A dose should then be withdrawn and injected into a 100-mL bag of 0.9% Sodium Chloride Injection USP. The final concentration of INTRON A should not be less than 10 million IU/100 mL.

Please refer to the MEDICATION GUIDE for detailed, step-by-step instructions on how to inject the INTRON A dose. After preparation and administration of INTRON A, it is essential to follow the procedure for proper disposal of syringes and needles.

INTRON A Solution for Injection in Vials
INTRON A Solution for Injection is supplied in two multidose vials. The solutions for injection do not require reconstitution prior to administration; the solution is clear and colorless.

The appropriate dose should be withdrawn from the vial and injected intramuscularly, subcutaneously, or intralesionally.

INTRON A Solution for Injection is not recommended for intravenous administration.

Solution for Injection in Multidose Pens
The INTRON A Solution for Injection Multidose Pens are designed to deliver 3 to 12 doses, depending on the individual dose, using a simple dial mechanism, and are for subcutaneous injections only. Only the needles provided in the packaging should be used for the INTRON A Solution for Injection Multidose Pen. A new needle is to be used each time a dose is delivered using the pen. To avoid the possible transmission of disease, each INTRON A Solution for Injection Multidose Pen is for single patient use only.

Please refer to the MEDICATION GUIDE for detailed, step-by-step instructions on how to inject the INTRON A dose. After preparation and administration of INTRON A, it is essential to follow the procedure for proper disposal of syringes and needles.

HOW SUPPLIED

INTRON® A Powder for Injection
INTRON A Powder for Injection, 10 million IU per vial and Diluent for INTRON A (Sterile Water for Injection USP) 1 mL per vial; boxes containing 1 INTRON A vial and 1 vial of INTRON A Diluent (NDC 0085-0571-02).

INTRON A Powder for Injection, 18 million IU per vial and Diluent for INTRON A (Sterile Water for Injection USP) 1 mL per vial; boxes containing 1 vial of INTRON A and 1 vial of INTRON A Diluent (NDC 0085-1110-01).

INTRON A Powder for Injection, 50 million IU per vial and Diluent for INTRON A (Sterile Water for Injection USP) 1 mL per vial; boxes containing 1 INTRON A vial and 1 vial of INTRON A Diluent (NDC 0085-0539-01).

INTRON A Solution for Injection in Multidose Pens
INTRON A Solution for Injection, 6 doses of 3 million IU (18 million IU) Multidose Pen (22.5 million IU per 1.5 mL per pen); boxes containing 1 INTRON A Multidose Pen, six disposable needles and alcohol swabs (NDC 0085-1242-01).

INTRON A Solution for Injection, 6 doses of 5 million IU (30 million IU) Multidose Pen (37.5 mil