t;1
impaired concentration - - 1 - - <1 3 14 3 8 5 3
amnesia ¶ 1 <5 - - - - 14 - - - - - - - -
confusion 8 2 <5 4 12 10 1 - - - - 2
hypoesthesia - - 1 <5 1 - - 10 - - - - - - - -
irritability 1 1 - - - - - - - - 13 16 12 22
somnolence 1 2 <5 3 3 - - 33# 14 9 5
anxiety 1 9 5 <1 1 3 5 2 - - 3
insomnia 5 4 - - <1 3 3 12 11 6 8
nervousness 1 1 - - 1 - - 3 2 3 - - 3
decreased libido 1 1 <5 - - - - - - 1 5 1 - -
other (<5%) abnormal coordination, abnormal dreaming, abnormal gait, abnormal thinking, aggravated depression, aggressive reaction, agitation (7% in chronic hepatitis B pediatrics), alcohol intolerance, apathy, aphasia, ataxia, Bell's palsy, CNS dysfunction, coma, convulsions, delirium, dysphonia, emotional lability, extrapyramidal disorder, feeling of ebriety, flushing, hearing disorder, hearing impairment, hot flashes, hyperesthesia, hyperkinesia, hypertonia, hypokinesia, impaired consciousness, labyrinthine disorder, loss of consciousness, manic depression, manic reaction, migraine, neuralgia, neuritis, neuropathy, neurosis, paresis, paroniria, parosmia, personality disorder, polyneuropathy, psychosis, speech disorder, stroke, suicidal ideation, suicide attempt, syncope, tinnitus, tremor, twitching, vertigo (8% in follicular lymphoma)
Reproduction System Disorders (<5%) amenorrhea (12% in follicular lymphoma), dysmenorrhea, impotence, leukorrhea, menorrhagia, menstrual irregularity, pelvic pain, penis disorder, sexual dysfunction, uterine bleeding, vaginal dryness
Resistance Mechanism Disorders
moniliasis - - 1 - - <1 - - 17 - - - - - - - -
herpes simplex 1 2 - - 1 - - 3 1 5 - - - -
other (<5%) abscess, conjunctivitis, fungal infection, hemophilus, herpes zoster, infection, infection bacterial, infection nonspecific (7% in follicular lymphoma), infection parasitic, otitis media, sepsis, stye, trichomonas, upper respiratory tract infection, viral infection (7% in chronic hepatitis C)
Respiratory System Disorders
dyspnea 15 14 <1 - - 1 34 3 5 - - - -
coughing 6 13 <1 - - - - 31 1 4 - - 5
pharyngitis 2 8 <5 1 1 31 3 7 1 7
sinusitis 1 4 - - - - - - 21 2 - - - - - -
nonproductive coughing 2 7 - - - - - - 14 0 1 - - - -
nasal congestion 1 7 - - 1 - - 10 <1 4 - - - -
other (≤5%) asthma, bronchitis (10% in follicular lymphoma), bronchospasm, cyanosis, epistaxis (7% in chronic hepatitis B pediatrics), hemoptysis, hypoventilation, laryngitis, lung fibrosis, pleural effusion, orthopnea, pleural pain, pneumonia, pneumonitis, pneumothorax, rales, respiratory disorder, respiratory insufficiency, sneezing, tonsillitis, tracheitis, wheezing
Skin and Appendages Disorders
dermatitis 1 - - 8 - - - - - - 2 1 - - - -
alopecia 29 23 8 - - 12 31 28 26 38 17
pruritus - - 10 11 1 7 - - 9 6 4 3
rash 19 13 25 - - 9 10 5 8 1 5
dry skin 1 3 9 - - 9 10 4 3 - - <1
other (<5%) abnormal hair texture, acne, cellulitis, cyanosis of the hand, cold and clammy skin, dermatitis lichenoides, eczema, epidermal necrolysis, erythema, erythema nodosum, folliculitis, furunculosis, increased hair growth, lacrimal gland disorder, lacrimation, lipoma, maculopapular rash, melanosis, nail disorders, nonherpetic cold sores, pallor, peripheral ischemia, photosensitivity, pruritus genital, psoriasis, psoriasis aggravated, purpura (5% in |
